OBJECTIVE To investigate the etiological characteristics of pulmonary infection in the stroke patients and analyze the diagnostic values of peripheral blood micro ribonucleic acid-193b (miR-193b), micro ribonucleic acid-127(miR-127) and micro ribonucleic acid-133(miR-133).

METHODS A total of 469 stroke patients who were treated in Xuzhou First People′s Hospital from Jan 2020 to Dec 2022 were enrolled in the study and were divided into the infection group with 116 cases and the no infection group with 353 cases according to the status of pulmonary infection. The current status and etiological characteristics of the pulmonary infection were analyzed, the expression levels of peripheral blood miR were detected, and the values in prediction of the pulmonary infection were analyzed by means of receiver operating characteristic (ROC)curves.

RESULTS The incidence of pulmonary infection was 24.73%(116/469) among the stroke patients. Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae and Candida albicans were the major species of pathogens causing the infection. The expression levels of peripheral blood miR-193b, miR-127 and miR-133 of the infection group were significantly higher than those of the no infection group (P < 0.05), which showed upward trends with the aggravation of the infection(P < 0.05). The area under curve (AUC) of the joint detection of peripheral blood miR-193b, miR-127 and miR-133 was 0.877 in prediction of the pulmonary infection in the stroke patients, with the sensitivity 85.34%, the specificity 77.05%.

CONCLUSION The incidence of pulmonary infection is high among the stroke patients, the pulmonary infection may result in the rise of expression levels of peripheral blood miR-193b, miR-127 and miR-133, and the joint detection of the three indexes has high value in prediction of the pulmonary infection in the stroke patients.