结核性胸膜炎胸腔积液BIRC5、sTREM-1和miR-506-3p表达水平及其对预后的预测价值

Expressions of BIRC5, sTREM-1 and miR-506-3p in pleural effusion of patients with tuberculous pleurisy and values in prediction of prognosis

    摘要
  • 摘要:
    目的 探究结核性胸膜炎患者胸腔积液含杆状病毒凋亡抑制蛋白重复序列蛋白5(BIRC5)、可溶性髓系细胞触发受体1(sTREM-1)、微小核糖核酸(miR)-506-3p表达水平及其对结核性胸膜炎患者预后的预测价值。
    方法 选取2021年3月-2023年3月保定市第二中心医院收治的98例结核性胸膜炎患者为研究组, 并根据预后情况分为预后良好组69例和预后不良组29例, 随机选取同期108例非结核性胸膜炎患者为对照组, 检测患者胸腔积液BIRC5、sTREM-1、miR-506-3p表达水平, 采用受试者工作特征(ROC)曲线分析BIRC5、sTREM-1、miR-506-3p表达对结核性胸膜炎预后的预测价值。
    结果 与对照组相比, 研究组胸腔积液BIRC5、sTREM-1水平升高, miR-506-3p水平降低(P＜0.05)；与预后良好组相比, 预后不良组胸腔积液BIRC5、sTREM-1水平升高, miR-506-3p水平降低(P＜0.05)；BIRC5、sTREM-1、miR-506-3p联合检测对结核性胸膜炎患者预后诊断的曲线下面积(AUC)值高于单独检测的AUC值(P＜0.05), 且联合检测的敏感度为86.21%, 特异度为94.20%。
    结论 结核性胸膜炎患者胸腔积液BIRC5、sTREM-1水平升高, miR-506-3p水平降低, 结核性胸膜炎预后不良患者也具有相同趋势, BIRC5、sTREM-1、miR-506-3p三者联合检测对结核性胸膜炎患者预后具有较高的预测价值。

     

    Abstract:
    OBJECTIVE To explore the expression levels of baculoviral inhibitor of apoptosis protein repeat-containing protein 5 (BIRC5), soluble myeloid cell trigger receptor 1 (sTREM-1) and micro ribonucleic acid (miR)-506-3p in pleural effusion of the patients with tuberculous pleurisy and analyze the values in prediction of prognosis.
    METHODS A total of 98 patients with tuberculous pleurisy who were treated in Baoding Second Central Hospital from Mar 2021 to Mar 2023 were assigned as the study group and were divided into the favorable prognosis group with 69 cases and the poor prognosis group with 29 cases according to the prognosis; meanwhile, 108 non-tuberculous pleurisy patients were chosen as the control group. The expression levels of pleural effusion BIRC5, sTREM-1 and miR-506-3p were detected for the patients. The values of BIRC5, sTREM-1 and miR-506-3p in prediction of prognosis of the patients with tuberculous pleurisy were analyzed by means of receiver operating characteristic (ROC) curves.
    RESULTS The levels of pleural effusion BIRC5 and sTREM-1 of the study group were significantly higher than those of the control group, and the miR-506-3p level of the study group was significantly lower than that of the control group(P < 0.05). The levels of pleural effusion BIRC5 and sTREM-1 of the poor prognosis group were significantly higher than those of the favorable prognosis group, and the miR-506-3p of the poor prognosis group was significantly lower than that of the favorable prognosis group(P < 0.05). The area under curve (AUC) of the joint detection of BIRC5, sTREM-1 and miR-506-3p was significantly higher than that of the single detection(P < 0.05), the sensitivity of the joint detection was 86.21%, with the specificity 94.20%.
    CONCLUSION The levels of pleural effusion BIRC5 and sTREM-1 of the patients with pleural effusion are elevated, while the miR-506-3p level is reduced. The tuberculous pleurisy patients with poor prognosis show the same trends. The joint detection of BIRC5, sTREM-1 and miR-506-3p has high value in prediction of the prognosis of the pleural effusion patients.

     

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