Abstract: Invasive candidiasis (IC) is the most common fungal infectious disease, which is difficult to diagnose clinically, accompanied by very high morbidity and mortality, and poses a serious disease burden to critically ill patients and immunocompromised individuals. Candida albicans has been the major causative agent of IC in most parts of the world, but in recent years, non-Candida albicans has gradually become the dominant species in some countries and regions, which has brought great difficulties in clinical management. This article reviews the latest epidemiologic progress of IC, and discusses in depth the current epidemiologic status of IC in high-risk populations as well as the trend of causative species, with the aim of providing new theoretical basis for the diagnosis and prevention of IC.