高危型HPV感染宫颈癌血清miR-18a和miR-34a-5p与miR-195的诊断价值

Values of serum miR-18a, miR-34a-5p and miR-195 in diagnosis of high-risk HPV infection in cervical cancer patients

    摘要
  • 摘要:
    目的 探讨高危型人乳头瘤病毒(HPV)感染宫颈癌血清微小核糖核酸(miR)-18a和miR-34a-5p与miR-195的诊断价值。
    方法 选取2022年1月-2023年7月河南大学淮河医院的高危型HPV感染宫颈癌患者77例为研究组，同期高危型HPV阳性宫颈鳞状上皮内病变患者79例为对照组。比较两组miR-18a、miR-34a-5p、miR-195水平；比较研究组不同特征患者miR-18a、miR-34a-5p、miR-195水平，分析三指标预测价值。
    结果 研究组血清miR-18a水平较对照组高(P < 0.05)，miR-34a-5p、miR-195水平较对照组低(P < 0.05)。研究组有淋巴结转移患者miR-34a-5p、miR-195水平较无淋巴结转移低(P < 0.05)，miR-18a水平比无淋巴结转移高(P < 0.05)，病理分期Ⅲ期患者miR-18a比病理分期Ⅰ~Ⅱ期高(P < 0.05)。三指标联合检测诊断高危型HPV感染宫颈癌的曲线下面积(AUC)比单独检测高(P < 0.05)，敏感度和特异度为81.80%和83.50%。
    结论 高危型HPV感染宫颈癌患者血清miR-18a呈高表达，miR-34a-5p、miR-195呈低表达，联合检测有助于诊断高危型HPV感染宫颈癌，三指标与HPV阳性宫颈癌患者不同特征有关。

     

    Abstract:
    OBJECTIVE To explore the values of serum microribonucleic acid (miR) -18a, miR-34a-5p and miR-195 in diagnosis of high-risk human papillomavirus (HPV) infection in the cervical cancer patients.
    METHODS Totally 77 cervical cancer patients with high-risk HPV infection who were treated in Huaihe Hospital, Henan University from Jan. 2022 to Jul. 2023 were assigned as the study group. Meanwhile, 79 high-risk HPV-positive patients who had cervical squamous intraepithelial lesions were chosen as the control group. The levels of miR-18a, miR-34a-5p amd miR-195 were compared between the two groups. The levels of miR-18a, miR-34a-5p and miR-195 were compared between the IL-17 methylation-positive patients and the IL-17 methylation-negative patients. The predictive values of the three indexes were analyzed, and the short-term curative effect of the different state of IL-17 methylation was observed.
    RESULTS The serum miR-18a level of the study group was higher than that of the control group(P < 0.05), while the levels of miR-34a-5p and miR-195 of the study group was lower than those of the control group(P < 0.05). In the study group, the levels of miR-34a-5p and miR-195 of the patients with lymphatic metastasis were lower than those of the patients without lymphatic metastasis(P < 0.05), while the miR-18a level of the patients with lymphatic metastasis was higher than that of the patients without lymphatic metastasis(P < 0.05); the miR-18a level of the patients with stage Ⅲ of pathological stage was higher than that of the patients with the pathological stage ranging between Ⅰ and Ⅱ (P < 0.05).The area under curve (AUC) of the joint detection of the three indexes was higher than that of the single detection in diagnosis of the cervical cancer patients with high-risk HPV infection(P < 0.05), the sensitivity was 81.80%, with the specificity 83.50%.
    CONCLUSIONS The cervical cancer patient with high-risk HPV infection show high expression of serum miR-18a and the low expressions of miR-34a-5p and miR-195. The joint detection of the indexes may facilitate the diagnosis of the cervical cancer patients with high-risk HPV infection. There is association between the three indexes and the characteristics of the HPV-positive cervical cancer patients.

     

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