OBJECTIVE To investigate the relationship between Helicobacter pylori (Hp) infection and serum homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP) and vitamin levels.

METHODS The physical examination indexes of people who underwent physical examination in the department of health medicine of the Second Medical Center of PLA General Hospital from Jan. 2019 to Nov. 2021 were retrospectively analyzed. The patients with Hp infection were assigned as the infection group, and the patients without infection were assigned as the control group. Multivariate logistic regression model was used to analyze the relationship between Hp infection and gender, age, body mass index (BMI), Hcy, hs-CRP, and vitamin levels.

RESULTS The hs-CRP and Hcy levels in Hp-infected patients were higher than those in the control group (P＜0.05). The levels of folate, vitamin A, vitamin B12, vitamin B6, vitamin C, and vitamin D3 of the infection group were lower than those of the control group (P＜0.05). After adjusting for sex, age, hs-CRP, Hcy, folic acid and vitamins, the results of multivariate logistic regression modeling found that the prevalence risk of Hp infection was rised in males (OR=1.290) using female as the reference, and age (OR=1.049), hs-CRP (OR=3.678), Hcy (OR=1.140) and vitamin B12 (OR=1.211), were positively correlated with the prevalence of Hp. Folic acid (OR=0.807), vitamin A (OR=0.171), vitamin B6 (OR=0.870), vitamin C (OR=0.858), vitamin E (OR=0.990), and vitamin D3 (OR=0.947) were negatively correlated with the prevalence of Hp.

CONCLUSION Elevated levels of Hcy and hs-CRP, and reduced folate, vitamin A, vitamin B12, vitamin B6, vitamin C, vitamin E, and vitamin D3 were associated with an increased prevalence of Hp infection.