OBJECTIVE To investigate the liver fibrosis and clinical characteristics of chronic HBV-infected patients, and to summarize the risk factors of significant liver injury.

METHODS Chronic HBV-infected patients attending the Hepatobiliary Center of Gansu Wuwei Tumour Hospital from Aug. 2018 to Jan. 2021 were included to observe the characteristics of liver fibrosis, and the risk factors for the occurrence of significant liver injury were explored by logistic regression model.

RESULTS Among the 3 753 chronic HBV-infected patients included in the study, they were categorized into five stages, F0-F4, according to the level of LSM, and differences in age, gender, smoking, antiviral treatment, HBV-family history, HCC-family history, AFP, ALT, AST, TBIL, DBIL, IBIL, ALB, GGT, CAP, and LSM were statistically significant at all stages of liver fibrosis. In untreated patients, age ≥ 45 years, HBeAg, AFP, ALT, DBIL, and GGT were risk factors for significant liver injury. Among patients after antiviral treatment, age ≥ 45 years, AFP, AST, TBIL, DBIL, GGT, and symptom of vomiting blood and black stool were risk factors for significant liver injury, while the CAP was a protective factor for significant liver injury.

CONCLUSION Age, HBeAg, AFP, ALT, AST, TBIL, DBIL, GGT, CAP levels, and symptoms of vomiting blood and black stool were the influencing factors of significant liver injury, and the clarification of the influencing factors was of great significance for the early monitoring of liver fibrosis and timely intervention to improve the quality of life of patients.