OBJECTIVE To analyze the association of peripheral blood CXC chemokine receptor 4 (CXCR4) and soluble triggering receptor expressed on myeloid cells-like transcription factor-1 (sTREM-1) with acute lung injury (ALI) in the patients with acute infectious peritonitis.

METHODS A total of 128 patients with acute infectious peritonitis who were treated in the First People′s Hospital of Hangzhou Lin′an District from Jan. 2021 to Jun. 2023 were recruited as the study objects and were divided into the ALI group with 40 cases and the no ALI group with 88 cases according to the status of ALI. The Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score, serum CXCR4 level and sTREM-1 level were compared between the two groups. Multivariate logistic regression analysis was performed for the influencing factors for ALI in the patients with acute infectious peritonitis. The efficiencies of the serum CXCR4 and sTREM-1 in prediction of ALI in the patients with acute infectious peritonitis were analyzed by means of receiver operating characteristic (ROC) curves.

RESULTS The levels of peripheral blood CXCR4, sTREM-1 and APACHE Ⅱ score of the ALI group were higher than those of the no ALI group (P < 0.05). Multivariate logistic regression analysis showed that the serum CXCR4 level, sTREM-1 level and APACHE Ⅱ score were the influencing factors for ALI in the patients with acute infectious peritonitis(P < 0.05). ROC curve analysis showed that the peripheral blood serum CXCR4 and sTREM-1 had efficiencies in prediction of ALI in the patients with acute infectious peritonitis, and the predictive efficiency of the joint detection of the two indexes was the highest(P < 0.05), the area under curve (AUC) was 0.909, with the sensitivity 90.00%, the specificity 73.86%.

CONCLUSION There is remarkable association between the levels of peripheral blood serum CXCR4, sTREM-1 and the occurrence of ALI in the patients with acute infectious peritonitis, and the two indexes can be used as predictive indexes.