幽门螺杆菌感染的不同阶段胃癌组织中微量元素及抗氧化因子的差异

Differences in trace elements and antioxidant factors in gastric cancer tissues at different stages of Helicobacter pylori infection

    摘要
  • 摘要:
    目的 探讨幽门螺杆菌(Hp)感染的不同阶段胃癌组织中微量元素及抗氧化因子的差异，为胃癌防治提供基础数据。
    方法 选取2021年3月-2024年2月于宣城市中心医院就诊的胃癌患者81例作为CA组，另选择同期就诊的慢性胃炎患者30例作为CG组，检测并比较两组患者血清微量元素及抗氧化因子的差异，以及幽门螺杆菌感染的不同阶段CA患者血清微量元素及抗氧化因子的差异。
    结果 CA组的血清铁(Fe)、锌(Zn)、镁(Mg)、钙(Ca)元素水平低，分别为(15.96±1.15)、(13.02±1.63)、(0.94±0.15)、(1.99±0.06)，铜(Cu)元素水平高，为(20.15±1.53)(P＜0.05)；CA-Hp(+)组的血清Fe、Ca元素水平低，分别为(15.90±0.45)、(1.94±0.45)，Cu元素水平高，为(20.54±2.64)(P＜0.05)；CA-Hp(+)(Ⅲ、Ⅳ期)的血清Fe、Zn、Mg元素水平低，Cu元素水平高(P＜0.05)；CA组的血清过氧化氢酶(CAT)、超氧化物歧化酶(SOD)水平低，分别为(56.93±6.36)、(3.75±0.33)，一氧化氮(NO)、丙二醛(MDA)水平高，分别为(63.55±5.54)、(9.23±0.32)(P＜0.05)；CA-Hp(+)组的血清CAT、SOD水平低，NO、MDA水平高(P＜0.05)；CA-Hp(+)(Ⅲ、Ⅳ期)的血清CAT、SOD水平低(P＜0.05)。
    结论 胃癌患者血清中微量元素及抗氧化因子表达情况与慢性胃炎患者存在差异，Hp感染、胃癌TNM分期是血清微量元素及抗氧化因子差异的影响因素。

     

    Abstract:
    OBJECTIVE To explore the differences in trace elements and antioxidant factors in gastric cancer tissues at different stages of Helicobacter pylori (Hp) infection, to provide basic data for the prevention and treatment of gastric cancer.
    METHODS Eighty-one patients with gastric cancer who visited the Xuancheng Central Hospital from Mar. 2021 to Feb. 2024 were selected as the CA group, and 30 patients with chronic gastritis during the same period were selected as the CG group. The differences of serum trace elements and antioxidant factors in the two groups were analyzed, as well as in different stages of Hp infection of CA patients.
    RESULTS Compared with CG group, low levels of serum Fe (15.96±1.15), Zn (13.02±1.63), Mg (0.94±0.15), and Ca (1.99±0.06) and high level of Cu (20.15±1.53) were observed in the CA group (P < 0.05). Compared with CA-Hp(-) group, serum Fe (15.90±0.45) and Ca (1.94±0.45) were low and Cu (20.54±2.64) was high in CA-Hp (+)group (P < 0.05), while the serum levels of antioxidant factors catalase (CAT) (56.93±6.36) and superoxide dismutase (SOD) (3.75±0.33) were low and nitric oxide (NO) (63.55±5.54) and malondialdehyde (MDA) (9.23±0.32) were high in the CA group (P < 0.05). The serum levels of CAT and SOD were low and NO and MDA were high (P < 0.05). Compared with staged Ⅰ and Ⅱ CA-Hp (+)group, serum Fe, Zn and Mg levels in staged Ⅲ and Ⅳ were low and Cu was high (P < 0.05), and the serum CAT and SOD levels were low(P < 0.05).
    CONCLUSION There are differences in serum trace elements and antioxidant factors in patients with gastric cancer and chronic gastritis, of which Hp infection and TNM staging of gastric cancer are influencing factors.

     

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