儿童肺炎支原体肺炎合并塑型性支气管炎外周血CCL11、LTB4、NEUT%和CRP表达及意义

Expressions of CCL11, LTB4, NEUT% and CRP in peripheral blood of children with MP pneumonia complicated with plastic bronchitis and their significance

    摘要
  • 摘要:
    目的 探究儿童肺炎支原体(MP)肺炎合并塑型性支气管炎外周血嗜酸细胞趋化因子11(CCL11)、白三烯B4(LTB4)、中性粒细胞百分比(NEUT%)和C-反应蛋白(CRP)表达及其意义。
    方法 选取2020年1月-2023年12月福建省龙岩市第二医院收治的80例肺炎支原体肺炎合并塑型性支气管炎患儿为研究组, 另随机选肺炎支原体肺炎患儿115例为对照组。统计两组临床资料、特征表现、第三代小儿死亡危险评分(PRISM Ⅲ)情况；比较两组外周血CCL11、LTB4、NEUT%和CRP水平差异；利用Pearson分析CCL11、LTB4、NEUT%和CRP水平与PRISM Ⅲ评分的相关性；分析CCL11、LTB4、NEUT%和CRP水平联合检测对肺炎支原体肺炎合并塑型性支气管炎患儿的诊断价值。
    结果 两组呼吸音降低、胸腔积液及PRISM Ⅲ评分比较, 差异有统计学意义(P＜0.05)。研究组和对照组外周血CCL11、LTB4、NEUT%和CRP水平比较, 差异有统计学意义(P＜0.05), 其中研究组CRP水平为(29.42±8.14)mg/L高于对照组(t=10.138, P＜0.001)。CCL11、LTB4、NEUT%和CRP水平与PRISM Ⅲ评分呈正相关(r =0.723、0.710、0.771、0.754, 均P＜0.001)。与CCL11、LTB4、NEUT%和CRP水平单一检测诊断肺炎支原体肺炎合并塑型性支气管炎患儿的曲线下面积(AUC)值相比, 四指标联合检测的AUC值更高(P＜0.05)。
    结论 CCL11、LTB4、NEUT%和CRP在肺炎支原体肺炎合并塑型性支气管炎患儿表达增加, 且四指标与PRISM Ⅲ评分呈正相关, 四指标对肺炎支原体肺炎合并塑型性支气管炎患儿诊断价值高。

     

    Abstract:
    OBJECTIVE To explore the expressions of eosinophilic chemotactic factor 11(CCL11), leukotriene B4 (LTB4), percentage of neutrophils (NEUT%) and C-reactive protein (CRP) in peripheral blood of the children with Mycoplasma pneumoniae (MP) infection complicated with plastic bronchitis and analyze the clinical significance.
    METHODS A total of 80 children with MP pneumonia complicated with plastic bronchitis who were treated in the Second Hospital of Longyan City, Fujian Province from Jan. 2020 to Dec. 2023 were assigned as the study group, and 115 patients with MP pneumonia were chosen as the control group. The clinical data, manifestations and Pediatric Risk of Mortality Ⅲ (PRISM Ⅲ) score were statistically analyzed. The levels of peripheral blood CCL11, LTB4, NEUT% and CRP were observed and compared between the two groups. Pearson analysis was performed for the associations of the levels of CCL11, LTB4, NEUT% and CRP with the PRISM Ⅲ score. The value of the joint detection of CCL11, LTB4, NEUT% and CRP in diagnosis of the MP pneumonia-induced plastic bronchitis was analyzed.
    RESULTS There were significant differences in reduction of bronchial breathing sound, pleural effusion and PRISM Ⅲ score between the two groups (P < 0.05). There were significant differences in the levels of peripheral blood CCL11, LTB4, NEUT% and CRP between the study group and the control group (P < 0.05); the CRP level of the study group was (29.42±8.14)mg/L, higher than that of the control group (t=10.138, P < 0.001). The levels of CCL11, LTB4, NEUT% and CRP were positively correlated with the PRISM Ⅲ score (r =0.723, 0.710, 0.771, 0.754, respectively, all P < 0.001). The area under the curve (AUC) of the single detection of CCL11, LTB4, NEUT% and CRP was remarkably higher in diagnosis of MP pneumonia-induced plastic bronchitis than that of the joint detection of the four markers (P < 0.05).
    CONCLUSIONS The children with MP pneumonia complicated with plastic bronchitis show increased expressions of CCL11, LTB4, NEUT% and CRP. The four markers are positively correlated with the PRISM Ⅲ score. The four markers have high values in diagnosis of the MP pneumonia complicated with plastic bronchitis.

     

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