OBJECTIVE To investigate the effect of the system inflammation response index (SIRI) on assessing the immune reconstitution in men with HIV after antiretroviral therapy (ART), and to provide laboratory indicators for monitoring dysfunctions following immune reconstitution from the perspective of inflammation.

METHODS In this study, the medical records and laboratory indicators of men with confirmed HIV infection who were admitted to Ningbo Yinzhou No.2 Hospital were retrospectively analyzed; according to CD₄⁺/CD₈⁺ ratio, the subjects were divided into poor-reconstituted group (< 0.71) and well-reconstituted group (≥0.71). The Mann-Whitney U rank-sum test were used to compare indicators between the two groups, Multivariate binary logistic regression analysis were used to screen the risk factors of poor immune reconstitution, and the receiver operating characteristic (ROC) curves were plotted to analyze the effect of risk factors on poor immune reconstitution.

RESULTS The neutrophils to lymphocytes ratio (NLR) and SIRI in the poor-reconstituted group were 1.53 and 0.59, respectively, lower than those in the well-reconstituted group 1.74 (P=0.004) and 0.82 (P < 0.001), respectively. The lymphocytes to monocytes ratio (LMR) in the poor-reconstituted group was higher than those in the well-reconstituted group 5.25 vs. 4.33 (P=0.002). The logistic regression analysis suggested that SIRI was an independent risk factor for poor immune reconstitution with OR 20.547 95%CI (1.742-242.317)(P=0.016), the area under the ROC curve for SIRI assessing poor immune reconstitution was 0.707 95%CI (0.609-0.805), P < 0.001, with the optimal cutoff value of 0.660, sensitivity of 69.60%, and specificity of 62.90%.

CONCLUSION SIRI is an independent risk factor and has certain assessing function for poor immune reconstitution after antiretroviral therapy in HIV infected men.