阜阳市6岁以下儿童支气管肺炎并发反复哮喘危险因素

Risk factors for recurrent asthma in children with bronchopneumonia under 6 years of age in Fuyang City

  • 摘要:
    目的 探讨阜阳市6岁以下儿童支气管肺炎并发反复哮喘的危险因素。
    方法 选择2021年1月-2025年1月阜阳市肿瘤医院收治的368例6岁以下患支气管肺炎的儿童为研究对象, 并依据是否并发反复哮喘分为哮喘组(n=130)与无哮喘组(n=238)。分析支气管肺炎季节性分布特征。采用最小绝对收缩和选择算子(LASSO)回归分析筛选预测因子, 纳入多因素logistic回归分析影响患儿并发反复哮喘的危险因素。
    结果 患儿在不同季节的发病例数有统计学差异(P<0.05), 以冬季为主。LASSO回归分析筛选出3个非零特征预测因子, 多因素logistic回归分析结果显示, 患儿具有家族哮喘史、接触粉尘或花粉、天气变化是儿童支气管肺炎并发反复哮喘的危险因素(P<0.05)。
    结论 温度变化使儿童发生支气管肺炎的概率具有明显的季节分布特征, 具体表现在寒冷的冬季为高发阶段, 夏季则发病概率相对较小。患儿存在家族哮喘史、接触粉尘或花粉、天气变化是支气管肺炎并发反复哮喘的重要危险因素。针对以上危险因素进行及时的预防和治疗, 对降低儿童支气管肺炎并发反复哮喘有重要意义。

     

    Abstract:
    OBJECTIVE To explore the risk factors for the recurrent asthma in children with bronchopneumonia under 6 years of age in Fuyang City.
    METHODS  A total of 368 children with bronchopneumonia who were less than 6 years old and treated in Fuyan Cancer Hospital from Jan. 2021 to Jan. 2023 were recruited as the research subjects and were divided into the asthma group with 130 cases and non-asthma group with 238 cases according to the status of recurrent asthma. The characteristics of seasonal distribution of the bronchopneumonia were analyzed. The predictive factors were screened out by the least absolute shrinkage and selection operator (LASSO) regression analysis, and multivariate logistic regression analysis was performed for the risk factors for the recurrent asthma in children.
    RESULTS There was significant difference in the number of cases among the seasons (P < 0.05), and it was most prevalent in winter. Three non-zero predictive factors were screened out by LASSO regression analysis. The result of multivariate logistic regression analysis showed that family history of asthma, contact with dust or pollen and weather change were risk factors for the recurrent asthma in children with bronchopneumonia (P < 0.05).
    CONCLUSIONS The change of temperature makes the probability of bronchopneumonia display a remarkable feature of seasonal distribution, which is highly prevalent in cold winter and less prevalent in summer. The family history of asthma, contact with dust or pollen and weather change are the major factors for the recurrent asthma in children with bronchopneumonia. It is of great significance to take targeted prevention and control measures based on the above risk factors so as to reduce the risk of recurrent asthma in children with bronchopneumonia.

     

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