OBJECTIVE To explore the prognostic values of serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1), pro-endothelin (pro-ET) and lipopolysaccharide (LPS) for neonatal infectious pneumonia (NIP).

METHODS A total of 110 neonates with NIP admitted to the Second Affiliated Hospital of Wenzhou Medical University from Jan. 2021 to Dec. 2023 were enrolled as the NIP group and further divided into good (69 cases) and poor prognosis group (41 cases) according to two-week prognosis after treatment. Clinical data and serum sTREM-1, pro-ET and LPS were compared between the two groups. The prognostic values were analyzed by receiver operating characteristic (ROC) curves.

RESULTS There were significant differences in birth weight, neonatal Apgar score, invasive operation, amniotic fluid contamination between the good and poor prognosis group (P < 0.05). The levels of serum sTREM-1, pro-ET and LPS at admission in poor prognosis group were significantly higher than those in good prognosis group (P < 0.05). ROC curves analysis showed that area under the curve (AUC) of serum sTREM-1, pro-ET and LPS at admission were 0.836, 0.810, 0.793, respectively, and the sensitivities were 80.65%, 54.84%, 58.06%, respectively. AUC and sensitivity of the combined detection were 0.872 and 83.87%, respectively (P < 0.05).

CONCLUSION The combined detection of serum sTREM-1, pro-ET and LPS has good predictive value for clinical NIP.