2019-2023年中山市住院儿童急性呼吸道感染7种病原体流行特征

Epidemiological characteristics of 7 species of pathogens causing acute respiratory infection in hospitalized children in Zhongshan City from 2019 to 2023

    摘要
  • 摘要:
    目的 分析2019-2023年广东中山地区儿童急性呼吸道感染的7种常见病原体。
    方法 选取2019年1月-2022年10月和2023年3-12月在中山市人民医院儿科住院的14 261例年龄在14岁及以下的急性呼吸道感染儿童作为研究对象, 比较新型冠状病毒感染(新冠疫情)流行前(2019年)、管控期(2020-2022年10月)以及常态化时期(2023年3-12月)7种常见呼吸道病原体阳性检出率。
    结果 新冠疫情流行前、管控期、常态化时期病原体总检出率为别为59.72%、37.83%、85.82%, 病原体检出率从高到低依次为肺炎链球菌(Spn)19.81%、呼吸道合胞病毒(RSV)11.33%、肺炎支原体(MP)9.53%、流感嗜血杆菌(Hi)5.90%、流感病毒A型(FluA)3.49%、腺病毒(ADV)3.30%、百日咳杆菌(BP)0.72%。流行前病原体混合感染率为8.46%, 主要为“MP+Spn”“Spn+RSV”；疫情管控期混合感染率分别为4.95%、4.65%、3.66%, 疫情常态化后混合感染率上升到17.75%, 主要为“Hi+Spn”“Spn+RSV”。RSV流行前、管控期、常态化时期检出率分别为7.82%、11.90%、14.44%, 并出现延迟流行；Spn流行前、管控期、常态化时期检出率分别为26.47%、17.45%、16.99%；MP流行前、管控期、常态化时期检出率分别为12.53%、1.83%、24.17%, 且出现延迟暴发流行。
    结论 针对新型冠状病毒感染的预防和控制, 采取了非药物的干预手段, 而后又取消了防控措施, 这7种常见的呼吸道病原的传播均受到影响, 因此需要对病原体进行持续监测。

     

    Abstract:
    OBJECTIVE To analyze the 7 species of common pathogens causing acute respiratory infection (ARI) in children in Zhongshan, Guangdong, from 2019 to 2023, and to provide references for preventive measures and clinical treatment of ARI.
    METHODS A total of 14 261 children with ARI aged 14 years and younger, hospitalized in the Pediatric Department of Zhongshan City People′s Hospital from Jan. 2019 to Oct. 2022 and from Mar. to Dec. 2023, were selected as the study subjects. The positive detection rates of seven common respiratory pathogens were compared across three periods: pre-pandemic period (2019), pandemic control period (from 2020 to Oct. 2022) and normalization period (from Mar. to Dec. 2023) of COVID-19.
    RESULTS The overall detection rates of pathogens were 59.72%, 37.83% and 85.82% in the pre-pandemic, control and normalization periods, respectively. The pathogens with the highest detection rates were Streptococcus pneumoniae (Spn) at 19.81%, respiratory syncytial virus (RSV) at 11.33%, Mycoplasma pneumoniae (MP) at 9.53%, Haemophilus influenzae (Hi) at 5.90%, influenza A virus (FluA) at 3.49%, adenovirus (ADV) at 3.30% and Bordetella pertussis (BP) at 0.72%. The mixed infection rate was 8.46% in the pre-pandemic period, mainly involving "MP+Spn" and "Spn+RSV". During the pandemic control period, the mixed infection rates were 4.95%, 4.65% and 3.66%, respectively. After the pandemic normalization, the mixed infection rate rose to 17.75%, mainly involving "Hi+Spn" and "Spn+RSV". The detection rates of RSV were 7.82%, 11.90% and 14.44% in the pre-pandemic, control and normalization periods, respectively, with a delayed epidemic pattern observed. The detection rates of Spn were 26.47%, 17.45% and 16.99% in the three periods, respectively. The detection rates of MP were 12.53%, 1.83% and 24.17%, respectively, with a delayed outbreak observed.
    CONCLUSIONS The prevention and control of COVID-19 involves non-pharmaceutical interventions, which are later lifted. The transmission of these seven common respiratory pathogens is affected, necessitating continuous monitoring of the pathogens.

     

    • HTML全文
    • 参考文献(26)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回
下载中心