IL-35和SRSF6水平与结核性胸膜炎胸膜厚度的关系及联合评估胸膜结核瘤发生风险的价值

Relationships between IL-35 and SRSF6 levels and pleural thickness in tuberculous pleurisy and joint assessments for pleurotuberculoma risk

    摘要
  • 摘要:
    目的 分析白细胞介素-35(IL-35)、富含丝氨酸-精氨酸剪接因子6(SRSF6)水平与结核性胸膜炎胸膜厚度的关系及联合评估患者胸膜结核瘤发生风险的价值。
    方法 选取2022年1月-2024年7月于浙江大学医学院附属第二医院临平院区收治的100例结核性胸膜炎。检测患者的胸腔积液IL-35、SRSF6水平及胸膜厚度。分析IL-35、SRSF6水平与结核性胸膜炎患者胸膜厚度的关系。随访1年，结核组患者根据是否发生胸膜结核瘤分为发生组与未发生组，分析结核性胸膜炎患者发生胸膜结核瘤的危险因素，分析IL-35和SRSF6评估结核性胸膜炎患者胸膜结核瘤发生风险的价值。
    结果 结核性胸膜炎患者的胸腔积液IL-35水平为(529.78±146.85)ng/L、胸腔积液SRSF6水平(1.44±0.43)ng/ml，胸膜厚度为(4.07±0.53)mm。结核性胸膜炎患者胸腔积液IL-35、SRSF6水平与胸膜厚度呈正相关(P＜0.05)。logistic分析显示，结核性胸膜炎患者出现胸水分隔包裹、胸膜厚度异常及胸腔积液IL-35、SRSF6水平上升时，其发生胸膜结核瘤的风险显著增加(P＜0.05)。绘制受试者工作特征(ROC)曲线分析显示，胸腔积液IL-35和SRSF6水平联合预测结核性胸膜炎患者发生胸膜结核瘤的曲线下面积(AUC)、特异度、灵敏度均高于两者单独检测值(P＜0.05)。
    结论 IL-35和SRSF6水平与结核性胸膜炎胸膜厚度呈正相关，两者联合检测可有效评估结核性胸膜炎患者胸膜结核瘤发生风险。

     

    Abstract:
    OBJECTIVE To analyze the relationship between interleukin-35 (IL-35) and serine/arginine-rich splicing factor 6 (SRSF6) levels and pleural thickness in patients with tuberculous pleurisy, as well as their values of joint assessment for the risk of pleural tuberculoma.
    METHODS A total of 100 patients with tuberculous pleurisy admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine, Linping Campus, from Jan. 2022 to Jul. 2024 were selected. The IL-35 and SRSF6 levels in pleural effusion and pleural thickness were measured. The relationship between IL-35, SRSF6 levels and pleural thickness were analyzed. After a one-year follow-up, patients with tuberculosis were divided into the occurrence group and non-occurrence group according to whether pleurotuberculoma developed. The risk factors for developing pleurotuberculoma and the value of IL-35 and SRSF6 in accessing the risk of developing pleurotuberculoma were analyzed.
    RESULTS In patients with tuberculous pleurisy, IL-35 and SRSF6 in pleural effusion was (529.78±146.85) ng/L and (1.44±0.43) ng/ml, respectively, and the pleural thickness was (4.07±0.53) mm. IL-35 and SRSF6 levels in pleural effusion were positively correlated with pleural thickness (P < 0.05). Logistic analysis showed that the risk of pleural tuberculoma significantly increased in patients with tuberculous pleurisy when there was pleural fluid separation, abnormal pleural thickness and elevated levels of IL-35 and SRSF6 in pleural effusion (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC), specificity and sensitivity of combined IL-35 and SRSF6 in predicting the occurrence of pleural tuberculoma in patients with tuberculous pleurisy were significantly higher than those of either marker alone (P < 0.05).
    CONCLUSION IL-35 and SRSF6 levels are positively correlated with the pleural thickness of tuberculous pleurisy, and the combined detection of IL-35 and SRSF6 can effectively assess the risk of pleural tuberculoma in tuberculous pleurisy patients.

     

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