Abstract:
OBJECTIVE To analyze the clinical characteristics of Pneumocystis jirovecii pneumonia (PJP) in non-human immunodeficiency virus (HIV) infected patients with different underlying diseases in the context of metagenomic next-generation sequencing technology (mNGS).
METHODS Totally 49 adults who were Pneumocystis jirovecii (PJ) positive and accepted mNGS test in the First Affiliated Hospital of Chongqing Medical University from Dec. 2018 to Dec. 2023 were enrolled and divided into PJP group (n=40) and PJ colonization (PJC) group(n=9); PJP group patients were further divided into four subgroups according to the types of underlying diseases: hematological malignancies (n=11), organ or hematopoietic stem-cell transplantation (n=9), autoimmune diseases (n=12) and chronic lung diseases and others (n=8). The clinical characteristics of each group were retrospectively collected and statistically compared.
RESULTS Among the PJP subgroups, the CD19+B lymphocytes count 0.50(0.00, 2.50)/μl and ratio of peripheral blood lymphocyte-to-monocyte (LMR) 0.60(0.43, 1.13) in the hematological malignancies group were the lowest (P < 0.05); monocytes count in peripheral blood and serum albumin(ALB) in autoimmune diseases group were the lowest (P < 0.05); the rates of admission to the intensive care unit(ICU) and ventilators application in chronic lung diseases and others group were the highest (P < 0.05).
CONCLUSION For non-HIV PJP patients, autoimmune diseases are the most common among various underlying diseases, which lead to different clinical characteristics.
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