OBJECTIVE  To investigate the distribution characteristics and antifungal sensitivity of Aspergillus spp., to optimize clinical treatment strategies for Aspergillosis.

METHODS  Clinical data on non-duplicate Aspergillus spp. isolates were collected from Peking University Shenzhen Hospital between Jan. 2020 and Jun. 2024 and analyzed. The VITEK MS system was used for identification of strains, and the YeastOne fungal susceptibility test kit was employed to determine the minimum inhibitory concentration (MIC) and minimum effective concentration (MEC).

RESULTS  A total of 864 strains of non-duplicate Aspergillus spp. were collected. The most common species identified were Aspergillus fumigatus (42.48%), followed by Aspergillus flavus (20.83%), Aspergillus niger (15.74%), and Aspergillus terreus (14.24%). Samples were primarily derived from sputum (58.33%) and bronchoalveolar lavage fluid (35.76%). The proportion of male (53.82%) was slightly higher than that of female (46.18%), and most patients were over 60 years old (57.98%), mainly from the department of respiratory medicine (47.45%) and the intensive care unit (16.09%). The MEC₉₀ of A. fumigatus and A. flavus for caspofungin and micafungin was ≤0.125 μg/ml, and MEC of A. terreus, A. niger, and A. nidulans was all ≤0.125 μg/ml.

CONCLUSIONS  The predominant Aspergillus spp. isolated from hospital is A. fumigatus, mainly from elderly male patients in the department of respiratory medicine and the intensive care unit. Aspergillus spp. demonstrates good sensitivity to azoles and echinocandins, while sensitivity of A. fumigatus to amphotericin B is relatively low.