OBJECTIVE  To evaluate the current status of bacterial contamination control and prevention measures and construction of quality control laboratory in Chinese blood station, and find out the problems and put forward the improvement suggestions.

METHODS  A total of 41 questionnaires were sent out for performance comparison by secretariat of working group of Chinese blood collection and supply institutions from May 2024 to Jun. 2024, and 40 questionnaires were received (14 blood centers and 26 central blood stations), 39 of which were valid. The questionnaire survey covered four aspects, including disinfection and surveillance, construction of quality control laboratory, sterility test for blood component and monitoring of blood transfusion reactions. The data were processed through itemized statistics and descriptive analysis.

RESULTS  Totally 84.62% of the blood stations used iodine-containing disinfectants for arm disinfection of the blood donors, and the monthly monitoring was the primary frequency. Among the quality control laboratories, 43.59% were registered as biosafety level 2, while 35.90% lacked biosafety registration. As for the pressure settings of the laboratories, 64.10% were under normal pressure, 15.38% under negative pressure and 17.95% under positive pressure. In the sterility test, the utilization rate of ultra clean operating tables and biological safety cabinets was 48.72%, the blood stations that did not have the indoor quality control accounted for 79.49%, and only 35.90% participated the external quality assessment. Regarding the approaches to confirm the positive result, 25.64% of the blood stations adopted the repeated tests, and 15.38% adopted the combination with positive culture bottle. The shortage of fund was the major restricted factor for the sterility test, and the confirmation of positive result was the fundamental difficulty. The blood stations with the feedback of insufficient transfusion reactions reported from hospitals accounted for 53.85%, while the blood stations that encountered suspected bacterial transfusion reactions with negative culture results accounted for 25.64%.

CONCLUSIONS  The infeciton control and prevention measures and the construction of quality control laboratory vary significantly in Chinese blood stations. The incomplete biosafety registration, non-standardized sterility test operation and weak surveillance of blood transfusion reactions are the major existing problems. It is suggested that the investment should be increased to push forward the standardization and complete the laboratory biosafety system, and a hospital-blood station closed loop coordination mechanism should be established so as to raise the blood safety.