OBJECTIVE To retrospectively analyze the drug resistance characteristics of the patients with multidrug-resistant organisms (MDROs) infections who were hospitalized from 2022 to 2023 and observe the effect of multidisciplinary teamwork (MDT) mode so as to provide scientific bases for prevention and control of MDROs infections and hospital-associated infections.

METHODS A total of 639 patients with MDROs infection who were hospitalized in Jianyang People′ s Hospital from Jan. 2022 to Dec. 2023 were recruited as the research subjects. The clinical data were collected from the patients, the drug resistance characteristics of bacteria were analyzed. The effects of MDT and pharmacological supervision on treatment of the patients with MDROs infection were observed and compared.

RESULTS The methicillin-resistant Staphylococcus aureus (MRSA) (359 strains, 56.18%) was dominant among the pathogens isolated from the 639 patients with MDROs infections, followed by the carbapenem-resistant Klebsiella pneumoniae (CRKP) (96 strains, 15.02%) and carbapenem-resistant Acinetobacter baumannii (82 strains, 12.83%). Of the patients with MDROs infection, 150 (23.47%) were from critical care medicine department, 94 (14.71%) from pediatrics department, and 82 (12.83%) from general surgery department. The result of drug susceptibility test showed that the S. aureus strains were susceptible to linezolid, daptomycin, vancomycin and tigecycline; most of the gram-negative bacteria were susceptible to carbapenems, while the A. baumannii strains were highly resistant to the commonly used antibiotics. The total isolation rate of MDROs and the case-time infection rate of MDROs infections were 14.32% and 0.05%, respectively, after MDT and pharmacological supervision were carried out, lower than those before carried out; the effective treatment rate of the patients with MDROs was 76.47% after MDT and pharmacological supervision were carried out, higher than that before they were carried out, and there were significant differences (all P < 0.05).

CONCLUSION MDT and pharmacological supervision may improve the curative effect of the patients with MDROs infection and reduce the isolation rate of MDROs as well as the incidence of hospital-associated infections.