新生儿蜡样芽孢杆菌晚发败血症2例并文献复习

Literature review of 2 cases of neonatal late-onset sepsis caused by Bacillus cereus

    摘要
  • 摘要:
    目的  通过对2例蜡样芽孢杆菌引起的新生儿晚发型败血症诊疗过程的分析，为临床诊治及感染防控提供参考。
    方法  收集2例蜡样芽孢杆菌引起的新生儿晚发败血症的症状、体征、实验室检查和诊疗过程，检索2010-2023年国内外蜡样芽孢杆菌引起的新生儿晚发型败血症，分析其感染特征、结局与预后、传播途径。
    结果  2例蜡样芽孢杆菌引起的新生儿晚发型败血症均死亡，其中1例发生脑实质出血；文献中的41例新生儿蜡样芽孢杆菌晚发败血症中，共死亡15例，病死率为36.59%。
    结论  蜡样芽孢杆菌引起的新生儿晚发败血症，临床常因延迟和失败的抗菌药物治疗导致病死率高，但发现污染来源后的感染防控措施是有效的。

     

    Abstract:
    OBJECTIVE  To analyze the diagnosis and treatment of 2 cases of neonatal late-onset sepsis (LOS) caused by Bacillus cereus, so as to guide the clinical diagnosis, treatment and infection control.
    METHODS  The symptoms, signs, laboratory test results, diagnosis and treatment of 2 cases of neonatal LOS caused by B. cereus were collected. Relevant literatures at home and abroad from Jan. 2010 to Dec. 2023 were retrieved and characteristics, outcome, prognosis and transmission routes of the B. cereus infection were analyzed.
    RESULTS  Both of the two newborns died, one of them occurred parenchymal hemorrhage. Fifteen out of 41 cases with LOS caused by B. cereus in the literatures died with the fatality rate 36.59%.
    CONCLUSION  The mortality of neonatal LOS caused by B. cereus is usually high due to delayed and failed antimicrobial therapy, but early detection of the sources of B. cereus contamination will contribute to the effective measures for prevention and control.

     

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