Abstract: Reports have revealed a high incidence of drug-resistant bacterial infections in war-related wounds of Russia-Ukraine conflict, posing challenges for treatment and attracting widespread attention from the international community and medical professionals. There are concerns that the Russia-Ukraine battlefield may stimulate the emergence of new bacterial drug resistance. This paper reviews the current status, causes and potential response strategies of drug-resistant bacteria in war-related wounds from the Russia-Ukraine conflict, and analyzes the profound impact of war and the existing war wound treatment system on the emergence and spread of bacterial drug resistance.