OBJECTIVE To explore the application of digital twin technology in modeling and simulating the hospital-associated transmission pathways of multidrug-resistant organisms (MDROs) and propose MDRO transmission prevention and control strategies based on digital twins.

METHODS Real-time hospital data and personnel mobility information from Jun.2023 to Jun.2024 were collected and analyzed.A dynamic model of the hospital′s internal environment and MDROs transmission was established by digital modeling and 3D simulation technology of the hospital environment.A simulation platform was utilized to analyze the impact of different prevention and control measures on MDROs transmission risks.Digital twin technology was employed for predicting and real-time monitoring of organism transmission pathways.

RESULTS Simulation data showed that under initial prevention and control conditions, Ward A had 8 infected individuals and a transmission duration of 12 days.After implementing comprehensive measures of "increased cleaning frequency+enhanced personnel protection", the number of infected individuals reduced to 4, the transmission duration shortened to 6 days and the transmission risk reduction rate reached 45.00%.The digital twin model can effectively reflect the transmission patterns of MDROs within the hospital and provide quantitative risk assessments under different prevention and control strategies.

CONCLUSIONS Digital twin technology can predict and simulate organism transmission pathways in real-time, providing scientific decision-making support for hospitals.It has the potential to become a new paradigm for MDROs prevention and control.