按蚊伊丽莎白菌感染流行病学及耐药机制研究进展

Progress of research on epidemiology and drug resistance mechanism of Elizabethkingia anopheles infection

  • 摘要: 近年来国内按蚊伊丽莎白菌(EA)检出率呈上升趋势, 是引发医院及社区感染的重要病原体之一。EA占伊丽莎白菌属59.3%~96.2%, 可引起脑膜炎、肺炎、菌血症等, 其致病机制的相关研究较少, 主要涉及多种毒力因子。EA是多重耐药菌, 耐药机制包括生物膜形成、外排泵、携带多个耐药基因(如GOBBlaB)等。目前米诺环素、哌拉西林/他唑巴坦、甲氧苄啶/磺胺甲噁唑、利福平作为有效治疗EA感染药物, 临床正在寻找最佳抗菌药物组合以达到理想治疗效果。本文针对EA流行病学特征、致病机制、耐药机制及治疗方案进行综述, 以期为临床防控、诊治EA感染提供参考。

     

    Abstract: In recent years the detection rate of Elizabethkingia anopheles(EA) in China has shown an upward trend, making it one of the important pathogens causing hospital and community infections. EA accounts for 59.3% to 96.2% of the Elizabethkingia species, and can cause meningitis, pneumonia, bacteremia, etc. There are limited researches on its pathogenic mechanism, which mainly involves various virulence factors. EA is a multidrug-resistant bacterium, with drug resistance mechanisms including biofilm formation, efflux pumps and carrying multiple resistance genes (such as GOB, BlaB). Currently, minocycline, piperacillin/tazobactam, trimethoprim/sulfamethoxazole and rifampin are effective drugs for treating EA infections. Clinically, efforts are being made to find the optimal antibacterial drug combination to achieve ideal therapeutic effects. This paper reviews the epidemiological characteristics, pathogenic mechanisms, drug resistance mechanisms and treatment options of EA, aiming to provide a reference for clinical prevention, control, diagnosis and treatment of EA infections.

     

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