Abstract: Healthcare-associated infections (HAIs) represent one of the critical issues affecting the public health security and the quality of medical services. Monitoring, early warning, intervention and feedback for HAIs remain the cornerstone of infection prevention and control. To systematically understand the progress of surveillance of HAIs in domestic and international regions and summarize the characteristics and variations, this paper comprehensively reviews the surveillance systems of HAIs from different regions around the globe, their construction and development as well as the diversity, covering the type of surveillance, surveillance idea and standards, the essential characteristics and advancements of the key technologies for HAIs surveillance and application systems were also compared among the regions. The review aims to summarize the general situation of development of HAIs surveillance in different regions around the globe and to provide new ideas for construction and development of HAIs surveillance system.