Abstract: Health economics evaluation serves as a pivotal tool for decision-makers to identify the most valuable health intervention program under the condition of resource constraints and optimize the resource allocation. In contrast to the health economics evaluation that was conducted abroad, domestic research remains in an exploratory phase. This paper undertakes a systematic review of the application progress and existing limitations of health economic evaluation methodologies in the infection prevention and control (IPC) field, aiming to offer insights and references for the standardized and in-depth development of health economic evaluations in the field of infection control, foster the practice of such evaluations in domestic settings, and push forward the sustainable advancement of China's IPC initiatives.