Abstract: Aortic endovascular stent infection (AEI) is a rare and potentially fatal complication following endovascular aortic repair (EVER). Its occurrence involves multiple factors. Actively preventing the colonization and adhesion of pathogenic microorganisms on the stent can significantly reduce the incidence rate of AEI. The clinical manifestations of AEI are nonspecific. Patients who develop unexplained fever, fatigue, pain or elevated inflammatory markers after EVER should be alerted to the possibility of AEI and require laboratory and imaging examinations to be improved actively for further clarification. For patients diagnosed with AEI who can tolerate surgery, the preferred treatment is to thoroughly remove infected materials and tissues, and to reconstruct blood supply and administer antibacterial therapy according to the patient′s condition. For those who cannot tolerate surgery, long-term or lifelong antibacterial drug therapy is required, which can be supplemented by percutaneous puncture drainage. Strict screening of EVER patients, active prevention of pathogen colonization, early diagnosis and multidisciplinary combination treatment can significantly reduce the incidence and fatality rate of AEI, thereby improving patient prognosis.