OBJECTIVE To explore the construction path and effectiveness of dynamic zoning management model during dengue fever pandemic, and to provide evidence for optimizing hospital-acquired infection control strategies.

METHODS Retrospective analysis method was conducted, the practical data of dengue fever epidemic prevention and control in a tertiary general hospital in 2024 as the sample, to evaluate the application effect of the "zoned treatment-dynamic allocation-environmental coordination" trinity prevention and control model. Based on the optimized infection prevention and control strategies implemented during the epidemic, such as the "core ward-specialist collaboration" dynamic zoning, flexible ward expansion, hierarchical disinfection, real-time dynamic resource allocation mechanism, and precise environmental intervention, a comprehensive evaluation of prevention and control efficiency was conducted across key dimensions including infection control, resource utilization, prevention and control costs and patient outcomes.

RESULTS Through the construction of flexible wards, the number of expanded isolation beds accounted for 44.13% (331/750) of the total beds, including 144 beds (19.20%) in core wards and 187 beds (24.93%) in specialist collaborative wards. The expansion of specialist collaborative wards increased the isolation admission capacity by 129.86%. The two types of wards admitted 57.27% of single-disease dengue patients and 42.73% of isolated patients with combined diagnosis and treatment needs from internal medicine, surgery, obstetrics, gynecology, and pediatrics. The minimum ratio of flexible buffer isolation beds was 6.34% (21/331), with a maximum daily treatment capacity of 310 patients. Data showed: hospital infection incidence rate was 0, peak adult mosquito density was 0.13 mosquitoes/trap·night, prevention and control cost was 95.22 yuan per case, and patient satisfaction increased by 1.98% (95.09 vs. 93.24, P=0.014).

CONCLUSIONS The "dynamic zoning" model achieves rapid spatial elastic reconstruction of inpatient wards for "peace-epidemic conversion" through the coordination of three links. Based on effectively blocking in-hospital transmission, it ensures the needs of multi-specialty treatment, enabling the hospital to strike a balance between the bottom line of prevention and control safety and the fulfillment of diversified medical service requirements during the epidemic outbreak period. It can provide standardized prevention and control solutions for medical institutions to respond to public health emergencies of vector-borne infectious diseases, and achieve the goal of zero cross infection of hospital-acquired Dengue.