OBJECTIVE To explore the use of carbapenems and β-lactamase inhibitors in a hospital before and after specialized management and control of antibiotics and carry out economic evaluation.

METHODS The patients who were hospitalized and treated with amoxicillin-clavulanate potassium, piperacillin-tazobactam, cefoperazone-sulbactam and meropenem in Nantong Third Hospital Affiliated to Nantong University from Jul. 2021 to Dec. 2021 (before the specialized management and control, 5086 cases) and from Jul. 2022 to Dec. 2022 (after the specialized management and control, 2040 cases) were recruited as the research subjects. The utilization rates of antibiotics, antimicrobial use density (AUD), rates of prophylactic use of type Ⅰ incision antibiotics, drug utilization indexes (DUIs), rates of rational advice, constituent ratios of antibiotics, minimum cost analysis of prophylactic antibiotics and costs of antimicrobial treatments were observed and compared before and after the specialized management and control.

RESULTS The utilization rates of amoxicillin-clavulanate potassium, piperacillin-tazobactam and cefoperazone-sulbactam were decreased from 5.23%, 11.70% and 3.30% before the specialized management and control to 3.01%, 3.56% and 1.62% after the specialized management and control (all P < 0.05), and the AUDs were decreased by 1.48, 40.15 and 3.22, respectively. The DUIs of the four types of antibiotics were closer to 1 after the specialized management and control than before the specialized management and control. The rates of rational advice for amoxicillin-clavulanate potassium, piperacillin-tazobactam and cefoperazone-sulbactam were higher after the specialized management and control than before the specialized management and control (all P < 0.05). The prophylactic use of β-lactamase inhibitors and carbapenems antibiotics for type Ⅰ incision was strictly under control; the costs of treatment of type Ⅰ, Ⅱ incisions were better (all P < 0.05) and the total costs of two categories of drugs for type Ⅰ, Ⅱ incisions were lower after the specialized management and control than before the specialized management and control (P < 0.05).

CONCLUSION The precise specialized management and control has achieved initial effect on carbapenems and β-lactamases inhibitors, which improves the rationality of clinical use of drugs and cuts the costs, and the efficacy of the management and control needs to be further improved and optimized.