Abstract: OBJECTIVE To analyze the outbreak situations of hospital-associated infections related to flexible endoscopes at home and abroad, and provide evidence for the prevention and control of hospital-associated infection outbreaks. METHODS Based on the Worldwide Database for Nosocomial Outbreaks, Pubmed and CNKI database, statistical analysis was conducted on the data of hospital-associated infection outbreak events related to flexible endoscopes. RESULTS A total of 46 outbreak events occurred in 14 countries and regions, with the peak period of outbreak reports from 2002 to 2006. The clearly identified infected departments/units were mainly the intensive care unit (30.61%), endoscopy room (16.33%) and respiratory department (10.20%). The distribution of pathogens was bacteria (85.11%), viruses (12.77%) and fungi (2.13%), with Pseudomonas aeruginosa (34.04%) being the predominant bacteria. The clearly identified sites of infection were mainly respiratory tract infections (42.62%), gastrointestinal system infections (18.03%) and bloodstream infections (18.03%). The clearly identified sources of infection were mainly medical equipment/devices (76.19%), with bronchoscopes (47.62%) being the primary source. The clearly identified risk factors were mainly flexible endoscopy examination (31.67%) and contaminated equipment (30.00%). The clearly identified molecular typing methods were mainly pulsed-field gel electrophoresis (60.53%) and polymerase chain reaction (18.42%). Among the events where environmental detection was conducted, 64.29% had positive results, and 82.86% of flexible endoscopes tested positive. The clearly identified routes of infection were invasive techniques (77.55%), contact transmission (20.41%) and respiratory transmission (2.04%). The main measures for invasive technique events were improvement of nursing/equipment (53.06%), strengthening of disinfection/sterilization (40.82%) and enhancement of environmental screening (30.61%). CONCLUSIONS Hospital-associated infection outbreak events related to flexible endoscopes have a wide impact, involve complex links, and are difficult to prevent and control. It is necessary to formulate targeted intervention measures based on their outbreak characteristics as early as possible to effectively prevent and promptly control outbreak situations.