Abstract: OBJECTIVE To explore the distribution of pathogens causing fungal infections in the emergency ICU patients with severe pulmonary tuberculosis who were treated with continuous venovenous hemofiltration (CVVH) and analyze the risk factors. METHODS By means of 1: 1 matched case-control study, a total of 134 patients with severe pulmonary tuberculosis who underwent CVVH in emergency department of the First Affiliated Hospital of PLA Air Force Medical University from Jun. 2022 to May 2024 were recruited as the research subjects, 67 of whom were complicated with fungal infections and were assigned as the infection group, 67 were not complicated with fungal infections and were assigned as the no infection group. The clinical data were collected form the patients. The distribution of pathogens causing fungal infections in the emergency ICU patients with severe pulmonary tuberculosis undergoing CVVH was observed. The risk factors for the fungal infections were analyzed by generalized estimating equation (GEE) fitting logistic regression model. RESULTS The 67 patients of the infection group were detected with 79 strains of pathogens, 55 of whom had single-strain infection, and 12 had dual-strains infections. Candida albicans (55.70%) was the predominant species, followed by Aspergillus fumigatus (16.46%). The result of GEE fitting logistic regression analysis showed that the course of pulmonary tuberculosis (OR=2.104,95%CI:1.485 to 2.980), hypoproteinemia(OR=10.813,95%CI:1.249 to 93.589), length of hospital stay no less than 7 days (OR=6.204,95%CI:2.309 to 16.667)and treatment with antibiotics no less than 7 days(OR=4.680,95%CI:1.563~14.017) were the risk factors for fungal infections in the emergency ICU patients with severe pulmonary tuberculosis who were treated with CVVH (P＜0.05). CONCLUSIONS C. albicans is dominant among the pathogens causing fungal infections in the emergency ICU patients with severe pulmonary tuberculosis who were treated with CVVH, followed by A. fumigatus. Some of the cases have dual-strains infections. The course of pulmonary tuberculosis, hypoproteinemia, length of hospital stay and treatment with antibiotics are the risk factors for the fungal infections in the emergency ICU patients with severe pulmonary tuberculosis who are treated with CVVH.