Abstract: OBJECTIVE To evaluate the current status of control of infections in Quanzhou by analyzing the surveillance data of health care-associated infections (HAIs) in 17 hospitals from 2021 to 2024 so as to provide bases for development of targeted improvement measures. METHODS The data regarding to 13 surveillance indexes for HAIs and 9 environmental hygiene surveillance programs were collected from 17 secondary or above healthcare institutions of Quanzhou from 2021 to 2024. The rates were observed and compared by chi-square test. RESULTS There was a generally favorable progressing trend in the 17 healthcare institutions during the 4 years. The infection (case-time) rate, incidence of VAP, incidence of MDROs infections and utilization rates of antibiotics of hospitalized patients showed downward trends (P＜0.05). The etiological submission rate increased before the antimicrobial treatment(P＜0.05). As for the environmental hygiene surveillance indexes, the qualified rate of disinfection endoscopes, qualified rate of dialysis water for bacteria, qualified rate of dialysate for endotoxin and qualified rate of dialysis water for endotoxin increased (P＜0.05). The prevention and control of the infections should be focused on the incidence (case-time) of type Ⅰ incision surgical site infections, prophylactic utilization rate of antibiotics for type Ⅰ incision surgery, compliance rate and accurate rate of hand hygiene of health care workers, qualified rate of hand hygiene surveillance and incidence of urinary catheter-related urinary tract infections. CONCLUSIONS The current status of management of HAIs is generally good in the secondary or above healthcare institutions of Quanzhou. However, it is necessary to enhance the targeted prevention and control of existing weakness so as to improve the management of HAIs.