Abstract: OBJECTIVE To investigate the risk factors for urinary tract infections in the male patients with urethral stricture and observe the distribution and drug susceptibility rates of pathogens causing the infections so as to provide guidance for clinical intervention to such group of patients after the admission. METHODS The clinical data were collected from 180 male patients with urethral stricture who were treated in urology department (voiding dysfunction subspecialty) of Xiangya Hospital, Central South University from Jan. 2022 to Dec. 2024 and were retrospectively analyzed. The enrolled patients were divided into the urinary tract infection group with 115 cases and the no urinary tract infection group with 65 cases; 153 patients were assigned as the single stricture segment group, and 27 patients were assigned as the multiple stricture segment group. The risk factors for urinary tract infections, distribution of pathogens and the result of antimicrobial susceptibility testing were observed. RESULTS Traumatic urethral stricture, urinary catheter or bladder fistula tube indwelling at the admission and posterior urethral stricture were the risk factors for the urinary tract infections in the male patients with single stricture segment of urethral stricture (P＜0.05). Multivariate logistic regression analysis confirmed that the catheter indwelling at the admission was the risk factor for the urinary tract infections in the patients with single stricture segment of urethral stricture (OR=6.909,95%CI:2.623 to 18.199,P＜0.001). Totally 67 strains of pathogens were isolated from 55 patients who were positive for urine culture, among which Escherichia coli (14 strains), Enterococcus faecalis (8 strains) and Klebsiella pneumoniae (6 strains) were dominant. CONCLUSIONS The incidence of urinary tract infections is high among the male patients with urethral stricture at the admission. It is necessary to attach great importance to the patients complicate with risk factors, launch the clinical intervention program to the patients with urinary tract infections as quickly as possible, and formulate individualized regiments for treatment of infections.