创伤性骨折患者术后肺部感染病原菌及危险因素

Risk factors and pathogens causing postoperative pulmonary infections in patients with traumatic fractures

  • 摘要: 目的 明确创伤性骨折患者术后肺部感染的危险因素及病原菌分布情况。方法 对2022年1月-2024年12月在山东第二医科大学附属诸城市人民医院接受手术的1 023例创伤性骨折患者进行回顾性分析,其中术后发生肺部感染患者127例(感染组),未发生患者896例(非感染组)。采用多因素logistic回归模型,对诱发术后肺部感染的独立危险因素进行筛选与分析。结果 全组术后肺部感染率为12.41%(127/1 023)。病原学分析显示,127例感染患者共培养出116株病原菌,其中革兰阴性菌构成比为75.86%,革兰阳性菌为24.14%。前5位病原菌依次为肺炎克雷伯菌(22.41%)、大肠埃希菌(20.69%)、铜绿假单胞菌(13.79%)、金黄色葡萄球菌(11.21%)、鲍曼不动杆菌(7.76%),116株病原菌中,多重耐药菌占20株(17.24%)。多因素分析显示,年龄≥65岁、有吸烟史、合并糖尿病、更高的损伤严重程度(ISS)评分、长手术时间、长术后卧床时间,被证实为创伤性骨折患者发生术后肺部感染的危险因素(P <0.05)。结论 创伤性骨折患者术后肺部感染风险受年龄、吸烟史、糖尿病、ISS评分、手术时间、术后卧床时间等多因素影响,病原菌以革兰阴性菌为主,需针对性采取防控措施以降低感染率。

     

    Abstract: OBJECTIVE To explore the risk factors for postoperative pulmonary infections in the patients with traumatic fracture and observe the distribution of pathogens. METHODS A total of 1023 patients with traumatic fracture who received surgical procedures in Zhucheng People's Hospital Affiliated to Shandong Second Medical University from Jan. 2022 to Dec. 2024 were enrolled in the study and were divided into the infection group with 127 cases and the non-infection group with 896 cases according to the status of postoperative pulmonary infections. The independent risk factors that induced the postoperative pulmonary infections were screened out and analyzed by using multivariate logistic regression model. RESULTS The incidence rate of postoperative pulmonary infections was 12.41%(127/1023). The etiological analysis showed that totally 116 strains of pathogens were isolated from the 127 patients with the infections, of which 75.86% were gram-negative bacteria, 24.14% were gram-positive bacteria. The top 5 species of pathogens were successively as follows: Klebsiella pneumoniae(22.41%), Escherichia coli (20.69%), Pseudomonas aeruginosa (13.79%), Staphylococcus aureus (11.21%), Acinetobacter baumannii(7.76%). Among the 116 strains of pathogens, there were 20 (17.24%) strains of multidrug-resistant organisms. Multivariate analysis indicated that the no less than 65 years of age, smoking history, complication with diabetes mellitus, high injury severity score (ISS), long operation duration and long postoperative bedridden time were proved as the risk factors for the postoperative pulmonary infections in the patients with traumatic fracture(P<0.05). CONCLUSIONS The age, smoking history, diabetes mellitus, ISS score, operation duration, postoperative bedridden time are the influencing factors for the postoperative pulmonary infections in the patients with traumatic fractures. The gram-negative bacteria are dominant among the pathogens. It is necessary to take targeted prevention and control measures so as to reduce the incidence of the infections.

     

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