Abstract: OBJECTIVE To investigate the epidemiological characteristics of recurrent infections (no less than 2 times) of hand, foot and mouth disease (HFMD) among children in Hebei Province. METHODS The clinical data were collected from 14 174 children with HFMD who were treated in Hebei Children's Hospital from Jan. 1, 2013 to Jun. 30, 2024 and were retrospectively analyzed. The children who experienced no less than 2 times of infections were screened out to establish the multiple-infection group, and the statistical analysis was performed based on type of pathogen causing the infection, time interval between the infections, seasons, sex and age. REUSLTS Among the 14 174 children with HFMD, the children with recurrent infections accounted for 1.35%, of whom 1.31% had two times of infections, and 0.035% had three times of infections; the average time intervals of the patients with two times of infections and the patients with three times of infections were (15.05±11.96) months and (12.4±8.3) months, respectively. The children aged between 1 and 3 years old were dominant among the children with the recurrent infections, and Other enteroviruses(EVU) predominated among the age groups. EVU was highly prevalent all throughout the years, and there were seasonal differences in Enterovirus 71(EV71) and EVU(P＜0.05). There were significant differences in the distribution of pathogens and the seasonal distribution between the children with recurrent infections and the children with single-time infection (P＜0.05); the EV71 was highly prevalent in spring. CONCLUSIONS The recurrent infections of HFMD in the children should not be ignored. EVU infection is the major type of infection and is highly prevalent in summer and the population aged between 1 and 3 years old. The children with EVU infection are dominant in the multiple infection group, while the proportion of children with EV71 infection is relatively low. It is necessary to focus on the key groups and seasons and carry out the precise prevention and control.