Abstract: OBJECTIVE To explore the effect of pharmacists' full-cycle closed-loop management on the rationality of antimicrobial agents administration, clinical therapeutic effects and health economics indexes of the HIV/AIDS patients complicated with pulmonary infections. METHODS Totally 231 AIDS patients complicated with pulmonary infections who were treated in The Third People's Hospital of Guilin City from Jan. 2019 to Dec. 2024 were recruited as the research subjects. The control group (118 cases) was treated with conventional therapy, and the intervention group was treated with the pharmacist intervention of the five-step path "pharmaceutical assessment,regimen formulation, implementation monitoring, dynamic surveillance, and feedback optimization". The indictors for reasonable use of antibiotics, clinical therapeutic effect and medical costs were observed and compared between the two groups. RESULTS The clinical cure rate of the intervention group was 92.04%, remarkably higher than 80.51% of the control group (P=0.012); the incidence of adverse reactions decreased by 57.14%(10.62% vs. 23.73%,P=0.008). The rate of unreasonable courses reduced by 93.33%(3.54% vs. 50.85%, P＜0.001); the defined daily dose systems(DDDs) decreased by 79.30%(P＜0.001). The result of health economics evaluation showed that the cost of antibiotics decreased by 93.74%(P＜0.001), the length of hospital stay was shortened by 5.31 d(P＜0.001), and the average saving of western medicine expenses per patient was 4 952.73 yuan. CONCLUSION The pharmacists' full-cycle closed-loop management can remarkably raise the rationality of antimicrobial treatment of the HIV/AIDS patients complicated with pulmonary infections (with the key indictor decreased by more than 90%), reduce the incidence of drug-induced adverse reactions and medical costs, and achieve remarkable health economics value.