Abstract: OBJECTIVE To investigate the epidemiological characteristics of community-acquired carbapenem-resistant Enterobacteriaceae (CRE) infection so as to provide bases for prevention and control of the community-acquired CRE infection. METHODS By means of retrospective descriptive study, a total of 1144 patients who were diagnosed with community-acquired CRE infection in Taihe Hospital Affiliated to Hubei University of Medicine from 2014 to 2024 were enrolled in the study. The demographic data, departments for treatment, infection sites, species of pathogens and results of drug susceptibility testing were collected by hospital electronic medical record system. RESULTS From 2014 to 2024, the number of the patients with community-acquired CRE infections showed an overall fluctuating upward trend, reaching a peak of 221 cases in 2023; the male patients and the elderly patients (with 60 to 74 years of age) were dominant, accounting for 60.84% and 35.66%, respectively. Among the patients, 36.19% were from internal medicine departments, and 34.70% were from surgery departments. carbapenem resistant Klebsiella pneumoniae (CRKP,63.02%) and carbapenem-resistant Escherichia coli(CREC,16.96%) were the predominant species of the isolated strains. The respiratory tract (62.67%) and urinary tract (16.70%) were the most common infection sites. The result of drug resistance analysis showed that the drug resistance rates of the CRKP strains to cephalosporins (cefazolin 88.55%, cefuroxime 88.95%); tetracycline and polymyxin B still showed high antibacterial activity. CONCLUSIONS The patients with community-acquired CRE infection are characterized by middle-aged and elderly male, respiratory tract of the major infection site, high-risk departments of internal medicine and surgery departments, and high drug resistance rates to cephalosporins. It is necessary to attach great importance to the prevention and control of community-acquired CRE infection and reasonably optimize the use of antibiotics.