循环监测在脓毒症诊断和病情评估中的应用进展

Progress in the application of circulatory monitoring in the diagnosis and assessment of sepsis

  • 摘要: 循环监测对脓毒症早期诊断、病情评估具有重要意义。新近提出的“脓毒症休克前状态”是基于平均动脉压和血乳酸水平判定的、介于脓毒症与脓毒性休克间的独立临床状态,这一概念对于评价病情程度、判断预后具有潜在价值。微循环障碍常早于体循环发生,是组织低灌注的早期信号。皮肤花斑评分、毛细血管再充盈时间、外周灌注指数及舌下微循环检测等是评估组织灌注、预测死亡风险的有效工具。根据血流动力学特征可将脓毒症分为具有不同病理生理机制和死亡风险的临床亚型,为精准治疗提供了依据。循环监测贯穿于脓毒症的诊断、疾病程度分级、判断预后及指导治疗全过程,整合体循环与微循环信息,对于推动脓毒症个体化管理具有重要临床意义。

     

    Abstract: Circulatory monitoring is of great significance for early diagnosis and disease assessment. The recently proposed "pre-shock" is an independent clinical state between sepsis and septic shock, determined based on mean arterial pressure and blood lactate levels. This concept has potential value in evaluating disease severity and predicting prognosis. Microcirculatory disorders often occur before systemic circulatory changes, serving as an early indicator of tissue hypoperfusion. Skin mottling score, capillary refill time, peripheral perfusion index and sublingual microcirculatory assessment are recognized as effective tools for evaluating tissue perfusion and predicting mortality risk. Sepsis can be classified into clinical subtypes with different pathophysiological mechanisms and mortality risks based on hemodynamic characteristics, offering a basis for precise treatment. Circulatory monitoring runs through the entire process of diagnosing sepsis, grading disease severity, predicting prognosis and guiding treatment. The integration of systemic and microcirculatory data holds significant clinical significance for enabling individualized management of sepsis.

     

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