Abstract: OBJECTIVE To compare the differences in expression levels of inflammatory factors among the patients with septic shock induced by virous viral infections and understand the association between the type of virus and the inflammatory response so as to provide bases for precise intervention. METHODS Totally 156 patients who had early stage of septic shock that was caused by single viral infection and were treated in intensive care unit (ICU) of Shengjing Hospital of China Medical University and the People's Hospital Of Langfang City from Jan. 2021 to Jun. 2025 were recruited as the research subjects and were divided into the influenza virus group with 38 cases, the adenovirus group with 45 cases, the cytomegalovirus group with 35 cases, and the EB virus group with 38 cases according to the types of viruses. The levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, C-reactive protein (CRP) and procalcitonin (PCT) were observed and compared among the groups within 24 hours of the admission before the treatment and after the treatment. The effective rate of treatment and 28-day survival rate were compared. RESULTS There was no significant difference in the baseline data among the four groups. Before the treatment, the levels of IL-6, TNF-α and IL-1β of the adenovirus group were highest(196.53±57.69, 105.39±32.77, 76.69±22.97)pg/ml, the cytomegalovirus group the lowest(116.19±38.17, 73.59±23.19, 47.13±14.11)pg/ml,and there were between-group differences (P＜0.001); there were no significant differences in the CRP and PCT. The levels of IL-6, TNF-α, IL-1β and CRP of the four groups declined after the treatment (P＜0.05), while the PCT level did not change; the levels of inflammatory factors of the adenovirus group remained highest, the cytomegalovirus group the lowest. There were no significant differences in the effective rate of treatment (60.5%-74.3%) and 28-day survival rate among the four groups. CONCLUSIONS There are significant differences in the levels of inflammatory factors among the patients with septic shock induced by virous viral infections, the adenovirus infection leads to the strongest inflammatory response, and the cytomegalovirus infection leads to the weakest inflammatory response. The conventional therapies can effectively reduce the inflammatory reactions of the patients and do not show any significant difference in the clinical therapeutic effect among the patients with various viral infections.