Abstract: OBJECTIVE To explore the current status of construction of regional sterile supply resources sharing centers in China and find out the existing problems so as to provide solid evidence for optimization of related policies. METHODS From May 2025 to June 2025, a questionnaire survey was conducted for the current status of construction of regional sterile supply resources sharing centers in 1764 medical institutions across 22 provinces (autonomous regions, cities) and Xinjiang Production and Construction Corps of China. RESULTS Among the 1764 medical institutions, 41.16% carried out the sharing service of sterile supply resources, the service providers were predominantly secondary and tertiary hospitals, while the clients were mainly primary and secondary hospitals. 96.22% of the service providers were driven by administrative factors, 67.21% of the clients chose the service due to the limitation of their own conditions, and there was significant difference in the distribution of types of driving factors between the service providers and the clients(χ²=285.440,P＜0.001). The number of served external hospitals (U=3288.500,P＜0.001) and the number of served instrument packages (U=4476.500,P＜0.001) were larger in the tertiary hospitals than in the secondary hospitals. The minimum service radius of 76.92% of the service providers was within 10 kilometers, and 73.95% of logistics and transportation responsibilities were borne by the clients. The contract signing rate was 94.36%, but the pricing mechanisms were different, and 66.67% of the service provides fixed the price based on the size of package. CONCLUSION At present, there are problems such as high dependency on administrative promotion, failed release of the full regional radiation capabilities of secondary hospitals, unreasonable planning of service radius and incomplete contract and pricing mechanisms in the construction of regional sterile supply resources sharing centers in China.