Abstract: OBJECTIVE To comprehensively and deeply evaluate the efficiency of infection management in the clinical wards of a comprehensive three-A hospital and analyze precisely so as to provide bases for targeted and operable measures for further improvement of infection management quality. METHODS Totally 51 clinical wards that were chosen from Beijing Tiantan Hospital, Capital Medical University from Jan. 2024 to Dec. 2024 were set as Decision-Making Units (DMUs). Data Envelopment Analysis (DEA) method was employed to systematically evaluate their comprehensive efficiency. RESULTS The average comprehensive efficiency of the 51 clinical wards was 0.32, with the average pure technical efficiency at 0.40, the average scale efficiency at 0.89. Among the clinical wards, there was 1 (1.96%) ward efficient for DEA, 32 (62.75%) wards weakly efficient, and 18 (35.29%) wards inefficient for DEA. CONCLUSIONS The hospital exhibits a low comprehensive efficiency of the infection management, predominated by the low efficiency of pure technology; it is mainly manifested in the insufficient hand hygiene compliance.