Abstract: Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus and is characterized by high incidence of infections， delayed wound healing and high risk of amputation. Its pathogenesis is closely associated with peripheral neuropathy， peripheral vasculopathy， metabolic disorders， immune dysfunction and local microcirculation disturbance. Conventional treatment modalities have certain limitations in controlling deep-seated infections and accelerating wound healing. As a local antimicrobial sustained-release material， antibiotic-loaded bone cement (ALBC) features the continuous release of high-concentration antibiotics at the wound site， which can exert potent antibacterial effects， fill dead space， and promote tissue repair. In recent years， it has been widely applied in the treatment of DFU. By elaborating on the pathogenesis of DFU， this paper focuses on analysis of the mechanisms of ALBC in local antibiotic release， biofilm formation and microcirculation improvement as well as regulation of carrier and drug-loading factors on antibacterial-repairing effect. Additionally， it summarizes the clinical advances in its combination with TCM internal and external therapies as well as modern surgical techniques， aiming to provide novel insights and regimens for clinical treatment and improve the prognosis of patients.