Abstract: OBJECTIVE To evaluate the impact of invasive catheter-related infections on medical resource consumption under the China Healthcare Security Diagnosis-Related Groups (CHS-DRG) payment system so as to provide decision-making support for hospital infection management in the context of DRG payment reform. METHODS The medical insurance settlement data and the health care-associated infection data were retrospectively collected from all of the cases who were settled under CHS-DRG at Xuanwu Hospital， Capital Medical University， from 2022 to 2024. The length of hospital stay， costs， profits/losses， and cost structures were observed and compared between the invasive catheter-related infection group and the non-infection group by means of case-control study combined with propensity score matching method. RESULTS From 2002 to 2024， a total of 46 patients who had invasive catheter-related infections were identified and distributed in 26 diagnosis-related groups, including 12 cases of ventilator-associated pneumonia(VAP), 9 cases of central-line-associated bloodstream infections (CLABSI) and 25 cases of catheter-associated urinary tract infections(CAUTI). The median length of hospital stay was 24.00 days， the median hospitalization cost was 181，732.98 yuan， the medial net loss per case was -74，139.00 yuan， and the aggregate net loss was as much as -5，261，284.57 yuan. As compared with the non-infection group， the average length of hospital stay of the infection group was increased by 14.00 days， the cost was increased by 115，140.04 yuan， and the loss was increased by 92，662.37 yuan， and there were significant differences (P＜0.001). In terms of cost structure， the cost of drugs and materials expenses of the infection group increased most remarkably， increasing by 29，433.41 and 29，163.83 yuan per case (P＜0.001). Among the patients with different sites of infection， the patients with CAUTI exhibited the most increase of length of hospital stay per case (15.00 days)， and the patients with CLABSI exhibited the most increase of costs per case (240，076.06 yuan). CONCLUSIONS Under the CHS-DRG payment mode， the invasive catheter-related infections impose a substantial burden on healthcare resource consumption and severely impair the operational efficiency of medical institutions. It is necessary to explore synergistic management pathways integrating infection control with hospital operation so as to drive the high-quality development of public hospitals through 'value-based infection control'.