Abstract: OBJECTIVE To analyze the epidemiological characteristics and distribution of pathogens of device-associated infections in intensive care units (ICUs) of 187 hospitals in Xinjiang Uygur Autonomous Region, and to provide scientific evidence for the management of device-associated infections in ICUs across the region. METHODS The Xinjiang Hospital Infection Surveillance Platform was utilized to collect data on ICU inpatients across Xinjiang in 2024, and the device-associated infections were summarized and analyzed. RESULTS The incidence of ventilator-associated pneumonia (VAP) was 1.46‰ among the hospitalized patients of ICUs in Xinjiang in 2024; the incidence was 2.63‰ in the secondary hospitals, 3.46‰ in the hospitals with 1 000 to 1 500 beds. The incidence of central line-associated bloodstream infections (CLABSI) was 0.20‰; the incidence was 0.23‰ in the secondary hospitals, 0.45‰ in the hospitals with 1 000 to 1 500 beds. The incidence of catheter-associated urinary tract infections (CAUTI) was 0.47‰; the incidence was 0.48‰ in the secondary hospitals, 0.94‰ in the hospitals with 1 000 to 1 500 beds. A total of 1 553 pathogens were detected, including 978 gram-negative bacteria (62.97%), 480 gram-positive bacteria (30.91%) and 95 fungi (6.12%). CONCLUSIONS In the device-associated infections in the ICUs across Xinjiang, the incidence rate of VAP is the highest. Although the incidence rate of CLABSI is relatively low, the consequences of infection are severe and still require significant attention. The main pathogens responsible for device-associated infections are predominantly gram-negative bacteria. Reasonable monitoring and prevention measures for device-associated infections can effectively reduce the occurrence of infections. Hospitals at all levels need to strengthen the standardized use of catheter-related devices and antimicrobial agents, and implement cross-departmental prevention and control measures to control device-related infections.