Abstract: OBJECTIVE To investigate level changes and clinical significance of serum TAM receptor in patients with tuberculosis, so as to provide new method and basis for the control of tuberculosis infection. METHODS A total of 48 tuberculosis patients who were admitted to hospital from Jul. 2015 to Dec. 2015 were selected as TB group, and 40 healthy persons who had contemporaneously visited Wuhan No.1 Hospital for routine examination were set as control group. Serum AXL, Mer and Gas6 levels were determined by enzyme linked immunosorbent assay (ELISA). RESULTS The serum AXL, Mer and Gas6 levels of TB group were (43.82 2.13) pg/ml,( 453.09 45.92) pg/ml, and (120.19 31.51)pg/ml, the level of serum AXL was significantly lower than that of control group with the same age, and the levels of Mer and Gas6 were significantly higher than those of control group with the same age (P＜0.05). CONCLUSION The change of AXL during infection is closely related to the degree of tuberculosis, which can be used as one of the indicators of tuberculosis staging, activity and prognosis. AXL plays a major role in inflammation resolution because of its high affinity with Gas6, the decrease of AXL level in tuberculosis patients suggests a defective inflammation resolution.