Abstract: OBJECTIVE To explore the key points of infection prevention and control in the transition process and early stage of closure of medical institutions that have been transferred to closed due to the outbreak of COVID-19.METHODS Based on the national technical guidelines for the prevention and control of COVID-19 and relevant documents, combined with the experience of participating in the prevention and control of COVID-19 in various places, the author explored and analyzed the common problems and the key points of infection prevention and control during the transition to close management and the initial period of closure due to the COVID-19 epidemic. RESULTS Hospitals transferred to closed-off management due to the outbreak of COVID-19 often encountered problems such as incompatibility of the original management system, lack of awareness of secondary control, and insufficient knowledge and skills.When transferred to closed management, epidemiological investigations should be actively carried out, management and control should be graded and classified, and various personnel in the hospital should be arranged reasonably.Infection prevention and control work should be quickly transferred into an anti-epidemic state.On the basis of meeting the needs of infection prevention and control, hospital reconstruction and air-condition use assessment should be carried out quickly, and attention should be paid to the infection risk prevention and control of personnel and treatment behaviors in the process of diagnosis and treatment.At the same time, it is necessary to pay attention to continuous infection risk monitoring, and achieve necessary terminal disinfection. CONCLUSION When medical institutions are transferred to closed-off management due to the outbreak of COVID-19, the risk of infection prevention and control involved in the process of functional transformation should be fully considered to prepare for the COVID-19 outbreak actively, and to accumulate experience in preventing possible future infectious diseases transmitted through the respiratory tract.