Abstract: OBJECTIVE To explore the influence of types of reproductive tract pathogen infection on expression levels of inflammatory factors. METHODS A total of 180 patients with genital tract infection who were treated in the Affiliated Hospital of Inner Mongolia Medical University from Oct 2019 to Oct 2020 were recruited as the study objects, including 63 male patients and 117 female patients. Cervical secretions specimens and prostatic fluid specimens were collected, the species of genital tract pathogens were detected by nucleic acid testing, blood specimens were collected, and the expression levels of inflammatory factors such as secreted immunoglobulin A（SIgA）, tumor necrosis factor alpha（TNF-α）, high-sensitivity C-reactive protein（hs-CRP）, interleukin-6（IL-6） and interferon gamma（IFN-γ） in peripheral blood were detected by using enzyme-linked immunosorbent assay. RESULTS There was no significant difference in the species of pathogens between the male patients and the female patients; the male patients with Ureaplasma urealyticum（UU） infection accounted for 74.60%, the female patients with Uu infection 74.36%. The WBC level of the patients with Neisseria gonorrhoeae（NG） infection was the highest, and the lymphocyte（LYM） level of the patients with Chlamydia trachomatis（CT） infection was the highest. The expression level of SIgA of the male patients with NG infection was the highest, and the expression level of SIgA of the female patients with Uu infection was the highest. There are significant differences in the expression levels of IL-6, hs-CRP and IFN-γ among the male patients with the infections of different species of pathogens（P＜0.05）, the expression levels of IL-6, hs-CRP and IFN-γ of the patients with Uu infection were the highest. There were significant differences in the expression levels of hs-CRP and IFN-γ among the female patients with the infections of different species of pathogens（P＜0.05）, and the expression levels of hs-CRP and IFN-γ of the patients with Uu infection were the highest. CONCLUSION The patients with reproductive tract infections of different species of pathogens vary in the expression levels of SIgA, IL-6, hs-CRP and IFN-γ. The understanding of the relationship between the changes of the indexes and the species of pathogens may facilitate the comprehensive assessment of illness condition and prevent further progression of disease.