Abstract: OBJECTIVE Systematic evaluation was conducted for the effect of carbon dioxide partial pressure difference of the static artery（V-ApCO₂） combined with central venous oxygen saturation（ScvO₂） on guided fluid resuscitation for septic shock.METHODS According to Cochrane collaborative network literature retrieval methods and combined retrieval of Chinese biomedical literature database（CBMdisc）, Chinese knowledge resources database（CNKI） and the Wan Fang data knowledge service platform, papers published before Oct. 31, 2018 on V-ApCO₂ combined with ScvO₂ guidance in septic shock fluid resuscitation during treatment were obtained. The standardized mean difference（SMD） or relative risk（RR） was used to evaluate the effects of V-ApCO₂ and ScvO₂ on fluid resuscitation and prognosis in patients with septic shock in the observation group and the control group.RESULTS A total of 12 eligible articles were included, including 818 patients with septic shock cases, among which 450 were in the observation group and 368 were in the control group. Meta analysis showed that the Acute Physiology and Chronic Health Evaluation（APACHE II） score, mechanical ventilation time, ICU hospitalization time and the 28 day mortality rate of the patients in the observation group after 6 h resuscitation were significantly lower than those in the control group, while the lactic acid clearance rate was significantly higher than that of the control groupf（P＜0.05）.CONCLUSION Combination of V-ApCO₂ and ScvO₂ as indicators of fluid resuscitation can help improve the prognosis of patients, reduce the time of mechanical ventilation and the length of stay in ICU, and decrease the fatality rate.