Abstract: OBJECTIVE To understand the psychological state of nursing staff during Corona Virus Disease（COVID-19） so as to provide basis for formulating psychological crisis interventions to emergency events.METHODS An online questionnaire survey was conducted for 1 097 nursing staff of Chinese PLA General Hospital from Feb.1, 2020 to Feb.18 2020, and the questionnaires included general information questionnaire, 9-item patient health questionnaire depression scale, generalized anxiety scale, insomnia severity index scale and mental health self-assessment questionnaire.RESULTS Of the nursing staff involved in the survey, 10.12%（111/1 097） had stress response, 27.53%（302/1 097） had mild depression, and 9.66%（106/1 097）had moderate and severe depression;24.07%（264/1 097） had mild anxiety, and 3.46%（38/1 097） had moderate and severe anxiety. 18.51%（203/1 097） had mild insomnia, 2.83%（31/1 097） had moderate and severe insomnia. There were no significant differences in the incidence rates of anxiety, depression and sleep disorders among the subjects of different genders, ages and educational levels; there were significant differences in the incidence rates of anxiety, depression and sleep disorder among the subjects with various degree of concern about COVID-19（all P＜0.05）, and the incidence of depression, anxiety, insomnia and stress response was increased with the increase of the degree of concerns about the COVID-19.CONCLUSION It is necessary for relevant departments to carry out the business competency training and psychological training for the nursing staff so as to enhance their psychological resilience, pay attention to their psychological needs and put forward specific psychological intervention measures.