Abstract: OBJECTIVE To observe the effect of Mongolian medicine batri-7 on recurrent respiratory tract infection (RRTI) in children and its effect on T lymphocyte subsets and serum immunoglobulin levels. METHODS Eighty cases of RRTI children admitted to the Affiliated Hospital of Inner Mongolia University of Nationalities from Nov. 2018 to Nov. 2019 were enrolled, which were divided into the e observation group and the control group by the random number assay, 40 cases in each group. According to the pathological detection, patients in the two groups were under symptomatic treatment, and the observation group of children were administered oral Mongolian bart-7 for a month after the treatment. The clinical efficacy , Chronic Cough Impact Questionnaire (CCIQ) and cough symptom scores before and after treatment, the T lymphocyte subsets (CD₃⁺, CD₄⁺, CD₈⁺ and CD₄⁺/CD₈⁺) and serum immunoglobulin (IgG, IgA, IgM) in the two groups of children were compared. Patients were followed up for 12 months and the onset frequency of acute respiratory tract infection between the two groups were compared between the two groups after 3, 6 and 12 months. RESULTS The clinical response rate in the experimental group (90.00%) was significantly higher than that in the control group (70.00%). (P<0.05). The CCIQ and cough symptom scores in the children of the two groups were significantly lower before the treatment than after the treatment (P<0.05), and the CCIQ and cough symptom scores in the observation group were significantly lower than that in the control group (P<0.05). CD₄⁺, CD₄⁺/CD₈⁺, IgG and IgA levels in the two groups before the treatment were significantly higher than that after the treatment (P<0.05). Compared with the control group, the levels of CD₄⁺, CD₄⁺/CD₈⁺, IgG and IgA in the observation group were significantly increased after treatment (P<0.05). The onset number of acute episodes of respiratory tract infection in the two groups increased gradually with the passage of time, and the differences between them were significant (P<0.05). Moreover, the number of acute episodes of respiratory tract infection in the observation group at 3, 6 and 12 months was significantly lower than that in the control group (P<0.05). CONCLUSION Mongolian medicine batri-7 had a good clinical effect on RRTI in children, and can effectively improve the T lymphocyte subsets and serum immunoglobulin levels of RRTI children.