OBJECTIVE To explore the clinical effect of Kangfuxin solution on wound healing, wound stromal cell-derived factor-1a (SDF-1a), vascular endothelial growth factor (VEGF) and angiopoietin-2 (ANG-2) of the perianal abscess patients complicated with wound infection.

METHODS A total of 118 perianal abscess patients complicated with postoperative wound infection who were treated in Wuhan Eighth Hospital from Jun. 2018 to Oct. 2023 were enrolled in the study and were randomly divided into the Kangfuxin solution group and the potassium permanganate group, with 59 cases in each group. Both groups were treated with debridement of infection foci in a timely manner, the potassium permanganate group was given potassium permanganate for daily cleaning and treatment, and the Kangfuxin solution group was given Kangfuxin solution for daily treatment. The wound healing time, time of disappearance of wound edema and shedding time of slough were recorded, and the reduced rate of wound surface was determined after the treatment. The pain degree was evaluated by visual analogue scale (VAS) after the treatment, and the levels of wound SDF-1a, VEGF and Ang-2 levels were detected.

RESULTS The wound healing time (12.53±2.57)days, time of disappearance of wound edema (6.89±1.06)days and shedding time of slough (3.06±0.68)days were shorter in the Kangfuxin solution group than in the potassium permanganate group (P < 0.05). The reduced rates of wound surface were higher after the treatment for 2, 7 and 14 days, the VAS score was lower, and there were significant differences(P < 0.05). The levels of SDF-1a, VEGF and Ang-2 of the two groups were higher after the treatment than before the treatment, the levels of SDF-1a, VEGF and Ang-2 of the Kangfuxin solution group were higher than those of the potassium permanganate group, and there were significant differences(P < 0.05).

CONCLUSIONS Kangfuxin solution can be used for wound repair of the perianal abscess patients complicated with wound infection, which may accelerate the wound healing. The action mechanisms may be associated with the regulation of expressions of wound SDF-1a, VEGF and Ang-2.