Abstract: OBJECTIVE To study and observe the change state of organism metabolism and nerve function indexes of patients with viral encephalitis,so as to provide evidence for the formulation of treatment measures. METHODS A total of 48 patients with viral encephalitis admitted in hospital from Mar. 2014 to Sep. 2015 were selected as observation group,and 48 healthy personnel of the same age at the same period were selected as the control group,then the cerebral oxygen metabolism,protein catabolism and nerve function indexes of two groups were respectively detected,then the inspection results of control group and observation group,observation group with different stages and EEG examination results were compared. RESULTS The cerebral oxygen metabolism indexes including oxygen extraction ratio(O₂ER)of observation group was(32.56±4.10)%,and it was higher than (22.14±2.56)% of control group,Oxygen saturation of mixed venose blood(SvO₂)and arterial oxygen content(CaO₂)were respectively (63.45±4.86)% and (124.56±10.31)ml/L,and they were all lower than (73.63±5.68)% and (171.84±15.22)ml/L of control group,the protein catabolism indexes of observation group were all lower than those of control group,the nerve function indexes were all higher than those of control group,and the inspection results of observation group with different stages and EEG examination results had significantly differences(P＜0.05). CONCLUSION The change of organism metabolism and nerve function indexes of patients with viral encephalitis are great,and the inspection results' differences of patients with different stages and EEG examination results are significantly too,so its clinical diagnosis value for the disease are higher.